Search results for "Tumour blood flow"
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Tumour Blood Flow Following Local Ultrasound Heating Computed from Thermal Clearance Curves
1987
Thermal clearance curves following termination of ultrasound-induced hyperthermia in human mammary carcinomas implanted into the flanks of nude rats were studied. They were found to be monoexponential in form, both with and without blood flow. From the difference between the inverse time constants with and without flow, the tumour blood flow rate could be calculated. Blood flow was found to increase with very short exposure times at the therapeutic hyperthermia temperature and subsequently decrease as the exposure time increased. A higher therapeutic hyperthermia temperature augmented this effect.
18F-FDG PET for breast cancer : combined analysis of tumour perfusion and metabolism for tumour characterisation and neoadjuvant chemotherapy respons…
2020
Neoadjuvant chemotherapy (NAC) is a common treatment in patients with locally advanced or large breast cancer at diagnosis. A pathological complete response (pCR) at the end of NAC is recognized as a good surrogate marker of relapse-free survival. An early identification of the pathological response has then become a key parameter to monitor new therapeutic strategies. Studies, focusing on predictive biomarkers identification, have shown that early changes in tumour metabolism, assessed by Positron Emission Tomography (PET) using 2-desoxy-2-18F-fluoro-D-glucose (18F-FDG), allow the early assessment of the pathological response at the end of treatment. However, given the diversity of breast …